Opportunity Information: Apply for W81XWH 17 LRP IA
The DoD Lupus, Impact Award (FY17 LRP Impact Award; Funding Opportunity Number W81XWH-17-LRP-IA) is a Department of Defense research funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA). Introduced for the first time in FY17, this award is designed to support lupus-focused research with the potential to significantly move the field forward. It is positioned to accommodate a wide range of project types and scientific approaches, as long as they are clearly centered on important scientific or clinical problems in lupus and are framed in a way that could produce a major, meaningful impact if the work is successful.
A central expectation of this mechanism is that applicants propose a well-formulated and testable hypothesis grounded in strong scientific rationale. That rationale should be demonstrated through careful reasoning and a critical analysis of existing evidence, including a thoughtful review of the published literature. While preliminary data are encouraged to strengthen the case that the project is feasible and that the hypothesis is plausible, they are not strictly required. In practice, applicants can bolster their proposal using unpublished observations from their lab and/or relevant findings already available in the lupus literature, as long as these data directly support the planned research direction.
The opportunity emphasizes several core review themes. First is impact: proposals should target an area of paramount importance to lupus disease, and the principal investigator is expected to explicitly spell out what the project could change in lupus research or patient-relevant understanding. Reviewers will be looking for a clear line of sight from the proposed experiments to the potential payoff, whether that payoff is a shift in scientific understanding, identification of new therapeutic targets, improved diagnostics, better stratification of patients, or other high-value advances relevant to lupus. Second is research strategy: the experimental plan and methods should show deep familiarity with lupus biology and the key challenges in the field. The strategy can be novel, but it can also be a strong, logically derived approach that builds from existing knowledge; what matters is that the methodology is rigorous and the reasoning is compelling.
A non-negotiable programmatic requirement is that the proposed research aligns with at least one of the FY17 Lupus Research Program (LRP) Focus Areas, meaning applicants must map their aims directly to those designated priorities for that fiscal year. Another important boundary is that clinical trials are not allowed under this program announcement, so projects must be designed accordingly (for example, mechanistic, preclinical, translational, or other non-trial clinical research approaches that do not meet the definition of a clinical trial, consistent with the solicitation rules).
From an administrative standpoint, the funding instrument may be a grant or a cooperative agreement, and the opportunity is categorized under science and technology/research and development (CFDA 12.420). Eligibility is broadly open (unrestricted) to any type of applicant organization, subject to any additional eligibility clarifications contained in the full announcement. The posting lists an expected five awards, with an award ceiling shown as 0 in the record (typically indicating that the ceiling is not specified in the summary field and applicants must consult the full solicitation for budget limits and constraints). The opportunity was created on October 18, 2017, with an original application deadline of January 4, 2018.Apply for W81XWH 17 LRP IA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Lupus, Impact Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Oct 18, 2017.
- Applicants must submit their applications by Jan 04, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD Lupus, Impact Award (FY17 LRP Impact Award; W81XWH-17-LRP-IA)
What is the DoD Lupus, Impact Award (FY17 LRP Impact Award)?
The DoD Lupus, Impact Award (FY17 LRP Impact Award; Funding Opportunity Number W81XWH-17-LRP-IA) is a Department of Defense research funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It was introduced for the first time in FY17 and is intended to support lupus-focused research with the potential to significantly move the field forward.
Who administers this funding opportunity?
The opportunity is administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) on behalf of the Department of Defense.
What is the main purpose of this award?
The award is designed to support research that is clearly centered on important scientific or clinical problems in lupus and is framed to produce a major, meaningful impact if successful. The mechanism is positioned to accommodate a wide range of project types and scientific approaches, as long as the work is lupus-focused and impact-driven.
What kinds of projects are a good fit?
A wide range of project types and scientific approaches may be responsive, provided they focus on lupus and target important scientific or clinical problems. The key expectation is that the project is designed in a way that could lead to major advances if the research succeeds.
Is a hypothesis required?
Yes. A central expectation is that the application proposes a well-formulated and testable hypothesis grounded in strong scientific rationale.
What does "strong scientific rationale" mean for this opportunity?
The rationale is expected to be demonstrated through careful reasoning and a critical analysis of existing evidence, including a thoughtful review of the published literature. Reviewers will be looking for a convincing argument that the hypothesis is plausible and the proposed direction is justified.
Are preliminary data required to apply?
Preliminary data are encouraged but not strictly required. Applicants can strengthen feasibility and plausibility using preliminary results, but the mechanism does not make preliminary data a hard requirement.
What types of data can be used to support the application if preliminary data are limited?
The announcement indicates applicants may support their proposal using unpublished observations from their lab and/or relevant findings already available in the lupus literature, as long as the information directly supports the proposed research direction.
What are the main review themes emphasized in this opportunity?
The opportunity emphasizes impact and research strategy. Impact focuses on targeting a paramount area of importance in lupus and clearly explaining what the project could change in lupus research or patient-relevant understanding. Research strategy focuses on the rigor and logic of the experimental plan and methods, including deep familiarity with lupus biology and challenges in the field.
What does the program mean by "impact"?
Impact refers to the potential for the proposed work to create a major payoff for lupus research or patient-relevant understanding. Reviewers will look for a clear line of sight from the proposed experiments to the potential benefit, such as shifting scientific understanding, identifying new therapeutic targets, improving diagnostics, improving patient stratification, or achieving other high-value advances relevant to lupus.
What does the program mean by "research strategy"?
Research strategy refers to how well the experimental plan and methods are designed and justified. The approach should demonstrate strong familiarity with lupus biology and key challenges in the field, and the methodology should be rigorous with compelling reasoning. The strategy may be novel or may build logically from existing knowledge, as long as it is well supported.
Is alignment with FY17 Lupus Research Program (LRP) Focus Areas required?
Yes. A non-negotiable programmatic requirement is that the proposed research aligns with at least one of the FY17 Lupus Research Program (LRP) Focus Areas. Applicants are expected to map their aims directly to the designated FY17 priorities.
Are clinical trials allowed under this funding opportunity?
No. Clinical trials are not allowed under this program announcement, so projects must be designed accordingly and remain within non-trial research approaches consistent with the solicitation rules.
If clinical trials are not allowed, what general kinds of research approaches does this opportunity imply are acceptable?
The description indicates projects should be designed as non-trial research approaches, such as mechanistic, preclinical, translational, or other clinical research approaches that do not meet the definition of a clinical trial, consistent with the solicitation rules.
What is the funding instrument for this opportunity?
The funding instrument may be a grant or a cooperative agreement.
What is the CFDA number and category for this opportunity?
The opportunity is categorized under science and technology/research and development and is listed under CFDA 12.420.
Who is eligible to apply?
Eligibility is described as broadly open (unrestricted) to any type of applicant organization, subject to any additional eligibility clarifications contained in the full announcement.
How many awards are expected to be made?
The posting lists an expected five awards.
Is there an award ceiling (maximum budget) listed in the posting?
The record shows an award ceiling of 0 in the summary field, which typically indicates the ceiling is not specified in that summary and applicants must consult the full solicitation for budget limits and constraints.
When was this opportunity created and what was the application deadline?
The opportunity was created on October 18, 2017. The original application deadline was January 4, 2018.
What is the key expectation applicants should address in their narrative about outcomes?
The principal investigator is expected to explicitly describe what the project could change in lupus research or patient-relevant understanding and connect the proposed experiments to that potential payoff.
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| DoD Lupus, Concept Award Apply for W81XWH 17 LRP CA Funding Number: W81XWH 17 LRP CA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Kidney Cancer, Concept Award Apply for W81XWH 17 KCRP CA Funding Number: W81XWH 17 KCRP CA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Kidney Cancer, Translational Research Partnership Award Apply for W81XWH 17 KCRP TRPA Funding Number: W81XWH 17 KCRP TRPA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Kidney Cancer, Consortium Development Award Apply for W81XWH 17 KCRP CDA Funding Number: W81XWH 17 KCRP CDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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| DoD Kidney Cancer, Idea Development Award Apply for W81XWH 17 KCRP IDA Funding Number: W81XWH 17 KCRP IDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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| DoD Accelerating Innovation in Military Medicine Research Award Apply for W81XWH 17 DMRDP AIMM Funding Number: W81XWH 17 DMRDP AIMM Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Field Initiated Projects Program: Minority-Serving Institution (MSI) -Research Apply for HHS 2018 ACL NIDILRR IFST 0243 Funding Number: HHS 2018 ACL NIDILRR IFST 0243 Agency: Department of Health and Human Services, Administration for Community Living Category: Science and Technology and other Research and Development Funding Amount: $200,000 |
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