Opportunity Information: Apply for PAR 21 307
The National Institutes of Health (NIH) funding opportunity titled "Dementia Care and Caregiver Support Intervention Research (R01 Clinical Trial Required)" (Funding Opportunity Number PAR-21-307) supports research to develop and test dementia care and caregiver support interventions for people living with Alzheimers disease (AD) and Alzheimers disease-related dementias (ADRD), as well as the family members, friends, and other caregivers who support them. The main purpose is to fund mechanism-focused intervention research that improves health, daily functioning, and overall well-being, while also addressing practical care needs that arise across the dementia trajectory. This is an R01 grant mechanism and it explicitly requires a clinical trial, meaning applicants should be prepared to conduct human-subjects research that prospectively evaluates an intervention and its effects on outcomes.
A defining feature of this FOA is its emphasis on the NIH Stage Model for behavioral intervention development, allowing projects spanning Stages I through V. In practice, that means NIH is inviting proposals that range from early-stage work (such as intervention design, refinement, and feasibility testing) through more advanced stages that include efficacy testing and later-stage effectiveness or implementation-oriented work. The focus on "mechanism-focused" research signals that NIH is looking for more than a program description or a service model; projects should be anchored in a clear explanation of how and why the intervention is expected to work, with outcomes and measures that can test those pathways. The overall expectation is that studies will generate actionable evidence about improving dementia care and caregiver support, not only whether an intervention helps, but what elements drive change and for whom.
The opportunity sits within NIHs health research mission (Funding Activity Category: Health) and is associated with CFDA number 93.866. While the announcement does not state an award ceiling or the number of expected awards in the provided excerpt, it is presented as a discretionary grant program administered by NIH. The FOA was created on 2021-08-11, with an original closing date listed as 2024-02-13, indicating a defined application deadline cycle for that round.
Eligibility is broad and includes many types of domestic applicants: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; and small businesses. In addition, the FOA explicitly calls out a wide set of "other eligible applicants" that NIH encourages or permits, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based and community-based organizations, regional organizations, U.S. territories or possessions, Indian/Native American tribal governments other than federally recognized ones, and non-U.S. entities (foreign organizations). Taken together, this breadth supports applications from academic research centers, health systems, community organizations, tribal and territorial entities, and cross-sector partnerships positioned to design and test real-world dementia and caregiver interventions.
In short, PAR-21-307 is aimed at building a stronger evidence base for dementia care and caregiver support by funding intervention development and testing across the full translational pipeline, with a strong expectation that studies will articulate and evaluate the mechanisms through which interventions improve outcomes for people living with AD/ADRD and those who care for them.Apply for PAR 21 307
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Dementia Care and Caregiver Support Intervention Research (R01 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2021-08-11.
- Applicants must submit their applications by 2024-02-13. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): NIH PAR-21-307
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Dementia Care and Caregiver Support Intervention Research (R01 Clinical Trial Required)" and it is associated with Funding Opportunity Number PAR-21-307.
Which agency is offering this grant?
This opportunity is offered by the National Institutes of Health (NIH).
What is the main goal of PAR-21-307?
The goal is to support research that develops and tests dementia care and caregiver support interventions for people living with Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD), as well as family members, friends, and other caregivers who support them. The focus is on improving health, daily functioning, and overall well-being while addressing practical care needs across the dementia trajectory.
What type of grant mechanism is used?
This opportunity uses the NIH R01 grant mechanism.
Does this FOA require a clinical trial?
Yes. The title explicitly states "Clinical Trial Required," meaning applicants should be prepared to conduct human-subjects research that prospectively evaluates an intervention and its effects on outcomes.
What kinds of projects does NIH want to fund under this FOA?
NIH is seeking intervention research that develops and tests dementia care and caregiver support interventions. A key expectation is that projects will generate actionable evidence about improving dementia care and caregiver support, including evidence about whether an intervention works and what elements drive change and for whom.
What does "mechanism-focused intervention research" mean in this announcement?
It means NIH is looking for more than a description of a program or service model. Proposed studies should include a clear explanation of how and why the intervention is expected to work (the mechanism), and they should use outcomes and measures that can test those pathways.
Who is the intended population for the interventions?
The interventions are intended for people living with Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD), and for the caregivers who support them (including family members, friends, and other caregivers).
What kinds of outcomes is NIH interested in improving?
The FOA highlights outcomes related to health, daily functioning, and overall well-being, along with practical care needs that arise across the dementia trajectory.
What is the NIH Stage Model, and how is it used in this FOA?
This FOA emphasizes the NIH Stage Model for behavioral intervention development and allows projects spanning Stages I through V. That means NIH is inviting proposals from early-stage work (design, refinement, feasibility testing) through later stages such as efficacy testing and more advanced effectiveness or implementation-oriented research.
Which NIH Stage Model stages are allowed for projects?
Projects may span NIH Stage Model Stages I through V.
Can early-stage intervention work be proposed (for example, feasibility testing)?
Yes. NIH is inviting proposals that include early-stage intervention design, refinement, and feasibility testing, consistent with the NIH Stage Model emphasis described in the opportunity.
Can later-stage testing be proposed (for example, efficacy or effectiveness studies)?
Yes. The FOA explicitly allows more advanced stages including efficacy testing and later-stage effectiveness or implementation-oriented work.
What is the funding activity category for this opportunity?
The Funding Activity Category is Health.
What is the CFDA number associated with this program?
The opportunity is associated with CFDA number 93.866.
Is this a discretionary grant program?
Yes. In the provided information, it is presented as a discretionary grant program administered by NIH.
When was this FOA created?
The FOA was created on 2021-08-11.
What is the application deadline mentioned in the provided information?
The provided information lists an original closing date of 2024-02-13 for that round.
Is an award ceiling or number of expected awards provided in the excerpt?
No. The provided excerpt does not state an award ceiling or the number of expected awards.
Which types of U.S. (domestic) organizations are eligible to apply?
Eligibility is broad and includes state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; and small businesses.
Are nonprofit organizations eligible?
Yes. The FOA includes nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories, as stated in the provided information).
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations other than small businesses, and it also separately includes small businesses.
Are small businesses eligible to apply?
Yes. Small businesses are explicitly included among eligible applicants.
Are institutions of higher education eligible?
Yes. The eligibility list includes public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal governments and tribal organizations eligible?
Yes. The FOA includes federally recognized Native American tribal governments and also Native American tribal organizations that are not federally recognized tribal governments. It also calls out Indian/Native American tribal governments other than federally recognized ones among "other eligible applicants."
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among the "other eligible applicants" listed in the provided information.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly included among the "other eligible applicants" referenced in the provided information.
Are minority-serving institutions (MSIs) and similar institution types included in eligibility?
Yes. The FOA explicitly lists Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs) among "other eligible applicants."
Are federal agencies eligible to apply?
Yes. The FOA includes eligible federal agencies among "other eligible applicants."
Are regional organizations eligible?
Yes. Regional organizations are explicitly listed among "other eligible applicants."
Are non-U.S. entities (foreign organizations) eligible?
Yes. The FOA explicitly includes non-U.S. entities (foreign organizations) among eligible applicants.
What is the overall emphasis of this FOA in one sentence?
PAR-21-307 aims to strengthen the evidence base for dementia care and caregiver support by funding clinical trial-based intervention development and testing across the translational pipeline, with a strong expectation that studies articulate and evaluate how interventions work, for whom, and through what mechanisms.
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| Deciphering Immune-CNS interactions in HIV utilizing in-vitro and in-vivo model systems (R21 Clinical Trial Not Allowed) Apply for RFA MH 21 251 Funding Number: RFA MH 21 251 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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| Longitudinal Single Cell Characterization of ADRD Postmortem Tissue (R01 Clinical Trial Not Allowed) Apply for PAR 22 029 Funding Number: PAR 22 029 Agency: National Institutes of Health Category: Health Funding Amount: $630,000 |
| NINDS Alzheimers Disease and Alzheimers Disease-Related Dementias (AD/ADRD) Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed) Apply for PAR 22 022 Funding Number: PAR 22 022 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Collaborative Partnership between Research Centers in Minority Institutions (RCMI) and Alcohol Research Centers (U54 Clinical Trial Optional) Apply for RFA AA 21 015 Funding Number: RFA AA 21 015 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| FY2022 AmeriCorps State and National Public Health AmeriCorps Apply for AC 09 08 21 Funding Number: AC 09 08 21 Agency: AmeriCorps Category: Health Funding Amount: Case Dependent |
| Detecting Cognitive Impairment, Including Dementia, in Primary Care and Other Everyday Clinical Settings for the General Public and Health Equity, Pragmatic Clinical Trials (U01 Clinical Trial Required) Apply for RFA NS 22 009 Funding Number: RFA NS 22 009 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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