High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional) | PAR 22 069

Opportunity Information: Apply for PAR 22 069

The High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional) opportunity (PAR-22-069) is a National Institutes of Health (NIH) grant program designed to push forward bold, cross-cutting research ideas that could open up entirely new directions of study within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The central aim is to fund projects that are genuinely high impact and interdisciplinary, meaning they should bring together expertise, tools, or concepts from different fields in a way that would not typically happen in a standard single-discipline research plan. NIDDK is looking for work that can meaningfully shift what is possible in the understanding, treatment, and prevention of diseases in its portfolio, rather than incremental advances.

A major theme of this funding opportunity is generating broadly useful outputs for the larger research community. That can take the form of creating a research resource (for example, a dataset, a platform, a novel assay or measurement approach, a computational tool, or another type of community-enabling capability) and/or carrying out discovery-based or hypothesis-generating science that produces new insights and directions others can build on. In other words, the program is oriented toward projects that reduce key bottlenecks, fill clear knowledge gaps, or introduce new technologies and research methods that accelerate progress across a field, not just within one lab. The FOA explicitly emphasizes novel approaches tied to unmet scientific opportunities, including efforts involving data generation, new technology development, or innovative methodologies that can change the pace or scope of what researchers can study in NIDDK-relevant areas.

The award uses the NIH RC2 mechanism, and clinical trials are optional, meaning applicants may propose studies that do or do not include a clinical trial component, depending on what best fits the scientific question and the resource or discovery goal. The activity category is listed under Food and Nutrition, Health, and the program is associated with CFDA number 93.847. The opportunity is categorized as discretionary funding and uses a grant funding instrument.

Eligibility is broad and includes many common NIH applicant types across government, academia, nonprofits, and industry. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other eligible entities. The FOA also highlights additional applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, Indian/Native American tribal governments other than federally recognized entities, and U.S. territories or possessions.

There are specific restrictions related to foreign participation. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as the primary applicant organization. However, non-domestic components of U.S. organizations are eligible, and foreign components are allowed as defined under the NIH Grants Policy Statement. This structure is fairly typical for NIH opportunities that want to enable international collaboration or specialized contributions without having the primary award made directly to a non-U.S. institution.

From an administrative standpoint, the opportunity was created on 2021-11-30 and lists an original closing date of 2024-10-30. The public summary does not specify an award ceiling or expected number of awards in the provided text, so applicants would typically confirm budget expectations, project period limits, and any special review considerations by consulting the full FOA on the NIH funding site and related NIDDK guidance. Overall, the program is best suited for teams proposing ambitious, integrative projects that either produce community-level resources or deliver discovery-driven results that can rapidly spark new lines of investigation across NIDDK mission areas.

• The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
• This funding opportunity was created on 2021-11-30.
• Applicants must submit their applications by 2024-10-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 22 069

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