Opportunity Information: Apply for PAR 20 181
The Limited Competition: National Primate Research Centers (P51) Program (Funding Opportunity Number PAR-20-181) is a National Institutes of Health (NIH) grant opportunity designed to support the ongoing operations and core activities of the National Primate Research Centers (NPRCs). The central idea behind the program is that nonhuman primates (NHPs) are among the most scientifically valuable animal models because they are the closest living relatives to humans in both physiology and genetics. That closeness makes NHPs uniquely important for biomedical research that aims to understand how human biology works under normal conditions and what changes when disease occurs. In practice, this includes both basic research (foundational biology and mechanisms) and translational research (work that helps move discoveries toward prevention, diagnosis, and treatment).
A major focus of the FOA is the recognition that high-quality primate research depends on specialized infrastructure, expert staff, and rigorous animal care standards. Maintaining NHP colonies and conducting research responsibly requires advanced husbandry, veterinary medicine, biosecurity, behavioral management, specialized facilities, and deep scientific expertise. Because these requirements are complex and expensive, the NIH emphasizes that it is most effective and economical to concentrate these resources in centralized primate centers rather than trying to replicate them across many separate institutions. The NPRC model is built around that efficiency: the centers maintain the animals, facilities, and technical capabilities and then make these resources available to investigators on a national basis, enabling researchers to access NHP models and related support systems that would otherwise be out of reach for many projects.
From an NIH mission standpoint, the NPRCs are positioned as enabling infrastructure. They are meant to complement and strengthen the work of NIH Institutes and Centers by providing the animals, expertise, and research environment needed for studies that rely on NHPs. Rather than being limited to a single disease area, the NPRCs function as broad, shared national resources that can support multiple biomedical priorities. This structure helps ensure that investigators who need NHP models can conduct rigorous studies in settings built to meet the scientific and ethical demands of primate research.
In terms of administrative details, this is a discretionary grant program in the health funding category, associated with CFDA number 93.351. The listed eligible applicants include public and state-controlled institutions of higher education, reflecting the fact that NPRCs are typically housed at major research universities with the scale and governance needed to run large primate facilities. The opportunity is described as a limited competition, which generally indicates that eligibility and applicant pool are restricted (for example, to existing centers or institutions meeting specific criteria outlined in the full FOA). The original closing date shown in the source data is 2023-05-25, and the funding opportunity was created on 2020-05-27.
The eligibility language also makes clear boundaries around foreign participation. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. At the same time, the FOA allows foreign components as defined in the NIH Grants Policy Statement, meaning certain project elements may be carried out abroad under NIH rules when properly justified and compliant, even though the primary applicant organization must be eligible and U.S.-based. For anyone considering this opportunity, the FOA itself is the definitive source for the full eligibility requirements and any additional conditions tied to the limited-competition structure.Apply for PAR 20 181
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: National Primate Research Centers (P51) Program" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351.
- This funding opportunity was created on 2020-05-27.
- Applicants must submit their applications by 2023-05-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education.
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Frequently Asked Questions (FAQs)
What is the funding opportunity called?
The opportunity is titled "Limited Competition: National Primate Research Centers (P51) Program" and is associated with Funding Opportunity Number (FON) PAR-20-181.
Who is offering this grant?
This is a National Institutes of Health (NIH) funding opportunity.
What is the main purpose of the National Primate Research Centers (P51) Program?
The purpose is to support the ongoing operations and core activities of the National Primate Research Centers (NPRCs), which provide specialized nonhuman primate (NHP) research infrastructure, expertise, and resources on a national basis.
What types of research does this program enable?
The NPRCs are positioned as enabling infrastructure for both basic research (foundational biology and mechanisms) and translational research (work that helps move discoveries toward prevention, diagnosis, and treatment) that relies on nonhuman primate models.
Why does the NIH emphasize nonhuman primates in this program?
The FOA highlights that nonhuman primates are among the most scientifically valuable animal models because they are the closest living relatives to humans in physiology and genetics. This makes them uniquely important for studies of normal human biology and how biology changes during disease.
What kinds of activities and capabilities are supported at NPRCs?
The FOA emphasizes that high-quality primate research requires specialized infrastructure, expert staff, and rigorous animal care standards. Examples of supported capabilities described include advanced husbandry, veterinary medicine, biosecurity, behavioral management, specialized facilities, and deep scientific expertise necessary to maintain NHP colonies and conduct research responsibly.
Why are primate research resources centralized in NPRCs instead of spread across many institutions?
According to the FOA description, maintaining NHP colonies and conducting research responsibly is complex and expensive. The NIH notes it is more effective and economical to concentrate these resources in centralized primate centers rather than replicate the same high-cost infrastructure and expertise across many separate institutions.
How do NPRCs serve the broader research community?
The NPRC model is described as making animals, facilities, technical capabilities, and related support systems available to investigators on a national basis, enabling researchers to access NHP models and expertise that may otherwise be out of reach for many projects.
Are NPRCs focused on a single disease area?
No. The NPRCs are described as broad, shared national resources that can support multiple biomedical priorities and complement the work of NIH Institutes and Centers rather than being limited to one disease area.
What type of grant program is this?
This is described as a discretionary grant program in the health funding category.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.351.
Who is eligible to apply based on the information provided?
The listed eligible applicants include public and state-controlled institutions of higher education, consistent with NPRCs typically being housed at major research universities.
What does "limited competition" mean in this context?
The opportunity is described as a limited competition, which generally indicates that eligibility and the applicant pool are restricted (for example, to existing centers or to institutions that meet specific criteria laid out in the full FOA). The FOA itself is the definitive source for the exact limited-competition requirements.
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply based on the eligibility language provided.
Are non-domestic components of U.S. organizations eligible to apply?
No. The information provided states that non-domestic components of U.S. organizations are also not eligible to apply.
Are any foreign activities allowed under this FOA?
Yes, the information provided indicates that the FOA allows "foreign components" as defined in the NIH Grants Policy Statement. This means certain project elements may be carried out abroad under NIH rules when properly justified and compliant, even though the primary applicant organization must be eligible and U.S.-based.
What is the listed closing date for this opportunity?
The original closing date shown in the source data is 2023-05-25.
When was this funding opportunity created?
The funding opportunity was created on 2020-05-27.
Where should applicants look for the definitive eligibility rules and conditions?
The FOA itself is described as the definitive source for the full eligibility requirements and any additional conditions tied to the limited-competition structure.
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