Opportunity Information: Apply for PA 18 397
The NIH Pathway to Independence Award (Parent K99/R00 - Clinical Trial Required), funding opportunity number PA-18-397, is a discretionary NIH grant designed to help exceptional postdoctoral researchers move quickly and successfully into independent, tenure-track (or equivalent) faculty positions. The core goal is to build and sustain a strong pipeline of new, NIH-supported investigators by bridging the gap between mentored postdoctoral training and fully independent research careers. In practice, the program supports a structured transition: an initial mentored phase meant to complete key career development and research milestones, followed by a subsequent independent phase intended to help the investigator establish a stand-alone research program and compete effectively for future NIH funding.
A defining feature of this specific announcement is its clinical trial requirement. It is meant for applicants who plan to be the lead investigator of an independent clinical trial, an independent clinical trial feasibility study, or an ancillary study that is separate from, but connected to, an existing clinical trial. In other words, the applicant is not simply getting exposure to clinical trials or participating under someone else’s leadership; they are proposing to take primary responsibility for an independent trial or trial-related study as part of their research and career development trajectory. Applicants who do not intend to lead an independent clinical trial (or who plan to gain experience on a trial led by another investigator) are directed to apply instead to the companion FOA, PA-18-398, which is aligned with non-independent clinical trial plans.
The program is broad in the types of organizations that can serve as applicants, reflecting NIH’s intent to support a wide range of research settings. Eligible applicants include many levels of government (state, county, city/township, special districts), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments, and Native American tribal organizations that are not federally recognized. It also includes public housing authorities/Indian housing authorities, nonprofits with and without 501(c)(3) status (when they are not institutions of higher education), for-profit organizations other than small businesses, small businesses, and other organizational types. The announcement also highlights categories of “other eligible applicants,” including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, tribal governments that are not federally recognized, and U.S. territories or possessions.
There are important limits related to foreign eligibility. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, “foreign components” as defined by the NIH Grants Policy Statement are allowed, meaning certain elements of the work may be conducted abroad under NIH rules even though the applicant organization itself must be domestic.
Administratively, this opportunity is offered by the National Institutes of Health as a grant mechanism and is associated with multiple CFDA numbers spanning NIH institutes and program areas (including, among others, 93.121, 93.172, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.361, 93.398, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.865, 93.866, and 93.867). The opportunity record shows an original closing date of 2019-01-07 and a creation date of 2017-11-29, and it does not specify an award ceiling or expected number of awards in the provided listing. Overall, PA-18-397 is best understood as a targeted K99/R00 pathway specifically for postdoctoral investigators who are ready to pair the transition to independence with leadership of an independent clinical trial or closely related independent clinical trial study.Apply for PA 18 397
- The National Institutes of Health in the education, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "NIH Pathway to Independence Award (Parent K99/R00 - Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.172, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.361, 93.398, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2017-11-29.
- Applicants must submit their applications by 2019-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Opportunities for Collaborative Research at the NIH Clinical Center (U01 - Clinical Trial Optional) Apply for PAR 18 646 Funding Number: PAR 18 646 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research on the Health of Women of Understudied, Underrepresented and Underreported (U3) Populations An ORWH FY18 Administrative Supplement (Admin Supp - Clinical Trial Optional) Apply for PA 18 676 Funding Number: PA 18 676 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Exploratory/Developmental Clinical Research Grants in Obesity (R21 Clinical Trial Optional) Apply for PA 18 720 Funding Number: PA 18 720 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Rare Diseases Clinical Research Consortia (RDCRC) for Rare Diseases Clinical Research Network (U54 Clinical Trials Optional) Apply for RFA TR 18 020 Funding Number: RFA TR 18 020 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $100,000 |
| Time-Sensitive Obesity Policy and Program Evaluation (R01 Clinical Trial Not Allowed) Apply for PAR 18 854 Funding Number: PAR 18 854 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Discovery of Biomarkers, Biomarker Signatures, and Endpoints for Pain (R61/R33 Clinical Trial Optional) Apply for RFA NS 18 041 Funding Number: RFA NS 18 041 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R21 Clinical Trial Not Allowed) Apply for RFA NS 18 042 Funding Number: RFA NS 18 042 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Analytical and/or Clinical Validation of a Candidate Biomarker for Pain (R61/R33 Clinical Trial Optional) Apply for RFA NS 18 046 Funding Number: RFA NS 18 046 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed) Apply for RFA NS 18 043 Funding Number: RFA NS 18 043 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Predoctoral Training in Advanced Data Analytics for Behavioral and Social Sciences Research (BSSR) - Institutional Research Training Program [T32] Apply for RFA OD 19 011 Funding Number: RFA OD 19 011 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA NS 19 010 Funding Number: RFA NS 19 010 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Translational Development of Devices to Treat Pain (U18 Clinical Trial Not Allowed) Apply for RFA EB 18 003 Funding Number: RFA EB 18 003 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $500,000 |
| HEAL Initiative: Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional) Apply for RFA NS 19 016 Funding Number: RFA NS 19 016 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain - (U44 Clinical Trial Not Allowed) Apply for RFA NS 19 020 Funding Number: RFA NS 19 020 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional) Apply for RFA NS 19 017 Funding Number: RFA NS 19 017 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $1,000,000 |
| Administrative Supplement for Research on Bioethical Issues Apply for PA 19 217 Funding Number: PA 19 217 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Required) Apply for RFA NS 20 008 Funding Number: RFA NS 20 008 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Required) Apply for RFA NS 20 010 Funding Number: RFA NS 20 010 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Developmental Centers for AIDS Research (P30 Clinical Trial Not Allowed) Apply for PAR 20 107 Funding Number: PAR 20 107 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Centers for AIDS Research (P30 Clinical Trial Not Allowed) Apply for PAR 20 106 Funding Number: PAR 20 106 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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