Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R01 Clinical Trial Optional) | PA 18 143

Opportunity Information: Apply for PA 18 143

The Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R01 Clinical Trial Optional) funding opportunity (PA 18-143) is a National Institutes of Health (NIH) discretionary grant program that supports research aimed at improving how symptoms are prevented, recognized, and managed in people living with long-term HIV, particularly older adults who are increasingly affected by HIV-associated Non-AIDS conditions (often referred to as HANA) and other chronic comorbidities. The core emphasis is on practical, innovative, and cost-effective strategies that can be developed, adapted, and tested to address symptom burden in this population, recognizing that as people with HIV live longer, they may face complex and overlapping health problems that are not classified as AIDS but still meaningfully affect quality of life, functioning, healthcare use, and long-term outcomes.

A key feature of the announcement is its focus on symptom management in the context of comorbidity. That means the research scope is not limited to HIV treatment alone, but instead targets the real-world clinical picture of aging with HIV, where individuals may experience multiple conditions and related symptoms at the same time. The FOA encourages work that moves beyond describing symptoms to creating and evaluating interventions or strategies that help prevent symptoms, detect them earlier, and manage them more effectively. Because the opportunity is labeled "Clinical Trial Optional," applicants can propose studies that do or do not involve clinical trials, depending on what is appropriate for the research question. In practice, this allows for a broad range of rigorous designs, including intervention development and testing when needed, as well as other approaches that can still produce actionable symptom management strategies.

The grant mechanism is an R01, which is the NIH Research Project Grant program intended for well-defined, substantial research projects. The activity category listed for this opportunity is Education and Health, and the CFDA number associated with it is 93.361. The announcement was created on 2017-11-07, and the original closing date listed in the source information is 2020-01-07. An award ceiling and expected number of awards are not specified in the provided data, which typically means applicants would need to consult the full FOA details or NIH institute guidance for budget expectations and funding outlook.

Eligibility is broad and includes many types of domestic U.S. organizations and, notably, certain non-U.S. entities. Eligible applicants listed include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those specific nonprofit categories); for-profit organizations other than small businesses; small businesses; and other applicants as allowed. The FOA also explicitly highlights additional eligible applicant categories, reinforcing an intent to include diverse institutions and community-based partners. These include Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); eligible federal agencies; faith-based or community-based organizations; Indian/Native American Tribal Governments other than federally recognized entities; regional organizations; U.S. territories or possessions; and non-domestic (non-U.S.) entities (foreign organizations).

Overall, this opportunity is designed to stimulate research that produces usable symptom management solutions for an aging population living with HIV and multiple health conditions. The intended impact is to improve day-to-day health and functioning through strategies that are not only clinically meaningful but also feasible and cost-conscious, reflecting the realities of healthcare delivery and the growing need for effective chronic care approaches in long-term HIV.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361.
• This funding opportunity was created on 2017-11-07.
• Applicants must submit their applications by 2020-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 18 143

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